Causes Atopic dermatitis

1 causes

1.1 genetics
1.2 hygiene hypothesis
1.3 allergens
1.4 hard water

causes

the cause of ad not known, although there evidence of genetic, environmental, , immunologic factors.

genetics

many people ad have family history of atopy. atopy immediate-onset allergic reaction (type 1 hypersensitivity reaction) manifests asthma, food allergies, ad or hay fever.

about 30% of people atopic dermatitis have mutations in gene production of filaggrin (flg), increase risk onset of atopic dermatitis , developing asthma. filaggrin plays important role in keeping skin surface acidic, hence giving anti-microbial effects. breaks down trans-urocanic acid, keeps ph low.

hygiene hypothesis

according hygiene hypothesis, when children brought exposed allergens in environment @ young age, immune system more tolerate them, while children brought in modern sanitary environment less exposed allergens @ young age, and, when exposed, develop allergies. there support hypothesis respect ad. exposed dogs while growing have lower risk of atopic dermatitis. there support epidemiological studies protective role helminths against ad. likewise children poor hygiene @ lower risk developing ad, children drink unpasteurised milk.

allergens

in small percentage of cases, atopic dermatitis caused sensitization foods. also, exposure allergens, either food or environment, can exacerbate existing atopic dermatitis. exposure dust mites, example, believed contribute 1 s risk of developing ad. diet high in fruits seems have protective effect against ad, whereas opposite seems true fast foods. atopic dermatitis appears associated celiac disease , non-celiac gluten sensitivity, , improvement gluten-free diet indicates gluten causative agent in these cases.

hard water

atopic dermatitis in children may linked level of calcium carbonate or hardness of household water, when used drink. far these findings have been supported in children united kingdom, spain, , japan.